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. 2016 Mar 25;2(3):e1501332. doi: 10.1126/sciadv.1501332

Fig. 5. Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice.

Fig. 5

(A) Effects of intraperitoneal injection of iODN2088 on inflammatory gene expression in WT peritoneal macrophages (n = 5 to 6). (B) Mac3 staining of epididymal fat obtained from fat-fed WT mice treated with iODN2088 or its control (Ctrl-iODN) (n = 5 to 6). Scale bar, 100 μm. (C) Effects of in vivo iODN2088 treatment on inflammatory gene expression in epididymal fat (n = 5 to 6). (D) Effects of in vivo iODN2088 treatment on the phosphorylation of IκBα in epididymal fat (n = 5 to 6). (E) Response to intraperitoneal injection of insulin (1.0 U/kg) in iODN2088-treated or Ctrl-iODN–treated mice (n = 5 to 6). (F) Effects of in vivo iODN2088 treatment on the expression of genes related to insulin sensitivity in epididymal fat (n = 5 to 6). §P = 0.08, *P < 0.05, **P < 0.01, and ***P < 0.001. All values are means ± SEM.