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. Author manuscript; available in PMC: 2016 Apr 4.
Published in final edited form as: Curr Alzheimer Res. 2015;12(1):32–46. doi: 10.2174/1567205012666141218140953

Fig. 3. Sequence variants of endothelin converting enzyme.

Fig. 3

ECE-1 is a type-II membrane protein with a variable N-terminal intracellular (IC) domain, and conserved transmembrane (TMD) and extracellular (Lumen) domains [153]. Through multiple alternate promoters, at least four isoforms of ECE-1 have been identified, each with unique intracellular domains that determine subcellular localization and tissue distribution, Isoforms 1a and 1c are primarily localized in the plasma membrane, whereas isoform 1b and 1d are predominantly located in late endosomes/multivesicular bodies and recycling endosomes, respectively [70, 119, 154].