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. 2016 Mar 29;7:11008. doi: 10.1038/ncomms11008

Table 3. Three genetic loci associated with spherical equivalent with a significant SNP × education interaction in Asians and results in European populations.

SNP (Chr:BP) Gene Allele FREQ Subgroup   Asians (n=10,315)     Europeans (n=40,036)  
          β P-value Phet β P-value Phet
rs12511037* (4:75334864) AREG C/T 0.91/0.95 Lower education 0.07 0.243   −0.05 0.323  
        Higher education −0.70 1.97 × 10−10   −0.03 0.579  
        SNP × education −0.89 6.87 × 10−11 0.704 0.02 0.176 0.284
        JMA   5.55 × 10−10 0.405   0.527 0.186
rs13215566 (6:89918638) GABRR1 C/G 0.94/0.84 Lower education −0.13 0.030   −0.03 0.258  
        Higher education −0.68 1.46 × 10−8   −0.01 0.817  
        SNP × education −0.56 8.48 × 10−5 0.134 −0.02 0.459 0.457
        JMA   3.81 × 10−8 0.122   0.502 0.630
rs12206610 6:166016800 PDE10A C/T 0.90/0.87 Lower education 0.16 0.008   0.01 0.759  
        Higher education −0.59 8.16 × 10−8   0.01 0.810  
        SNP × education −0.72 2.32 × 10−8 0.920 −0.002 0.421 0.111
        JMA   9.21 × 10−9 0.902   0.954 0.305

β (higher education/lower education), β-coefficient corresponds to the effect in spherical equivalent (dioptres) for 1 additional copy of the effect allele in the higher/lower education group; β (SNP × education), β-coefficient corresponds to the difference in spherical equivalent (dioptres) for 1 additional copy of the effect allele in the higher versus lower education group; FREQ, allele frequency of the effect allele in Asian/European cohorts; JMA, joint meta-analysis on SNP effect and SNP × education interaction effect on spherical equivalent; LD, linkage disequilibrium; Phet, P-value for the test of heterogeneity; SNP, single-nucleotide polymorphism.

β and P-values for SNP × education interaction were calculated by the meta-analysis of conducting a 1df Wald's test of single interaction parameter. Allele is listed as effect allele/other allele.

*SNP rs12511037 was not present in European studies after quality control. Here we present the results of a proxy SNP rs1246413 (T/G, frequency of risk allele T=0.95) in LD with rs12511037 (r2=0.97).