Figure 6. High-γ activity in the seizure core decreases in amplitude and frequency before seizure termination.

(a) High-γ instantaneous amplitude and multiunit firing recorded from an example microelectrode through the duration of the same seizure shown in Fig. 5b. The blue dotted line indicates linear regression of the peak high-γ amplitude for each discharge during the pre-termination epoch, and the orange dotted line similarly indicates peak firing rate. (b) Spectrogram of the same seizure in a. The white dotted line indicates peak high-γ frequency through the duration of the seizure, and the blue dotted line indicates linear regression of the peak high-γ frequency during the pre-termination epoch. c and d show the same seizure as in a and b recorded on the ECoG electrode adjacent to the microelectrode array. Dotted lines indicate the same linear regression measurements as in a and b.