Table 2.

Allelic diversity of Bexsero vaccine antigens per patient age group, MRF-MGL invasive meningococcal disease isolate genomes, England and Wales, 2010/11–2012/13 (n = 1,344)

Age (years)	NadA D (95% CI)	NHBA D (95% CI)	FHBP D (95% CI)	PorA VR1 D (95% CI)	PorA VR2 D (95% CI)
< 1 (n = 300)	0.31 (0.24–0.38)	0.88 (0.86–0.91)	0.89 (0.87–0.91)	0.82 (0.78–0.85)	0.88 (0.86–0.90)
1–4 (n = 315)	0.39 (0.33–0.46)	0.88 (0.86–0.90)	0.90 (0.88–0.92)	0.84 (0.81–0.87)	0.92 (0.91–0.94)
5–14 (n = 99)	0.33 (0.21–0.44)	0.91 (0.88–0.94)	0.91 (0.88–0.94)	0.88 (0.85–0.92)	0.91 (0.89–0.94)
15–24 (n = 168)	0.42 (0.33–0.52)	0.90 (0.88–0.92)	0.90 (0.88–0.92)	0.88 (0.85–0.90)	0.93 (0.92–0.95)
25–39 (n = 73)	0.50 (0.36–0.64)	0.92 (0.90–0.95)	0.93 (0.91–0.95)	0.84 (0.79–0.90)	0.93 (0.91–0.96)
40–64 (n = 173)	0.42 (0.33–0.51)	0.91 (0.89–0.93)	0.90 (0.88–0.92)	0.87 (0.84–0.90)	0.92 (0.91–0.94)
≥ 65 (n = 207)	0.41 (0.32–0.49)	0.87 (0.84–0.90)	0.85 (0.81–0.89)	0.82 (0.78–0.86)	0.91 (0.89–0.92)
Total (n = 1,344)	0.39 (0.36–0.42)	0.91 (0.91–0.92)	0.91 (0.91–0.92)	0.87 (0.86–0.88)	0.92 (0.92–0.93)

CI: confidence interval; MRF-MGL: Meningitis Research Foundation Meningococcus Genome Library.

Diversity determined by Simpson’s Diversity Index