Table 4.
Utility of biomarkers in differentiating cirrhosis with alcoholic hepatitis from cirrhosis with acute decompensation from etiologies other than alcohol: Receiver operating characteristics analysis
| Biomarker | AUC (95%CI) |
| Citrulline and betaine | 0.835 (0.747, 0.978) |
| Betaine and phenylalanine | 0.810 (0.684, 0.937) |
| Citrulline and phenylalanine | 0.758 (0.609, 0.907) |
| Citrulline | 0.758 (0.610, 0.907) |
| Betaine | 0.732 (0.588, 0.877) |
| Phenylalanine | 0.715 (0.567, 0.863) |
| Crotonobetaine | 0.663 (0.498, 0.827) |
| Tyrosine | 0.650 (0.484, 0.817) |
| Butyrobetaine | 0.649 (0.489, 0.808) |
| Creatinine | 0.645 (0.486, 0.805) |
| Octenoyl-carnitine | 0.631 (0.488, 0.774) |
| Propionyl-carnitine | 0.620 (0.453, 0.787) |
| Homocitrulline | 0.618 (0.457, 0.779) |
| Trimethyl-lysine | 0.616 (0.447, 0.784) |
| Butyryl-carnitine | 0.615 (0.451, 0.778) |
| Pentanoyl-carnitine | 0.613 (0.455, 0.771) |
| Choline | 0.597 (0.432, 0.762) |
| Valine | 0.588 (0.424, 0.752) |
| Lysine | 0.559 (0.393, 0.725) |
| Methyl-lysine | 0.552 (0.383, 0.721) |
| Iso-leucine | 0.548 (0.379, 0.716) |
| Acetyl-carnitine | 0.543 (0.375, 0.710) |
| Hexanoyl-carnitine | 0.529 (0.362, 0.696) |
| TMAO | 0.521 (0.347, 0.695) |
| Argine | 0.507 (0.339, 0.675) |
| ADMA | 0.481 (0.314, 0.647) |
| Leucine | 0.477 (0.309, 0.644) |
| Carnitine | 0.470 (0.301, 0.638) |
| MMA | 0.453 (0.286, 0.620) |
| SDMA | 0.447 (0.277, 0.617) |
| Dimethyl-lysine | 0.417 (0.243, 0.592) |
| Ornithine | 0.351 (0.186, 0.517) |
AUC: Area under receiver operating characteristics curve; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; MMA: Monomethylarginine; TMAO: Trimethylamine N-oxide.