Table 3.
Expanding TCRβ sequence clonotypes with ≥80% identity to published HCV-specific TCRβ sequences.
| Clonotype (patient) | Day detected | Fold increase | TRBV | TRBJ | Junction sequence | Matched accession | % Identity | Matched TRBV/TRBV |
|---|---|---|---|---|---|---|---|---|
| 670 (pt 1) | 14 | 4.5 | 7–6, 7–7, or 7–9 | 2–2 | CASSQSQTGNTGELFF | ADQ19362.1 | 81 | No |
| 3765 (pt 3) | 28 | 3.9 | 10–3 | 2–3 | CAISTSGRGTDTQYF | ADQ19287.1 | 87 | Yes |
| 9961 (pt 4) | 14 | 23.9 | 19 | 2–6 | CASSISDSGANVLTF | ADQ19329.1 | 80 | No |
| 9052 (pt 4) | 28 | 12.5 | 28 | 2–7 | CASSLGSGTTYEQYF | ADQ19416.1 | 80 | No |
| 2026 (pt 5) | 14 | 83.8 | 6–1, 6–5, or 6–8 | 2–2 | CASRTGSSDTGELFF | ADQ19381.1 | 87 | No |
| 6896 (pt 5) | 28 | 7.1 | 7–6 | 2–2 | CASSSRTGVNTGELFF | ADQ19362.1 | 88 | No |
| 10020 (pt 5) | 84 | 42.0 | 6–1 | 2–2 | CASRTGSSDTGELFF | ADQ19381.1 | 87 | No |
| 372 (pt 6) | 14, 84 | 220.5, 102.5 | 7–2 | 1–1 | CASSDRDGGWTEAFF | ADQ19336.1 | 80 | No |
| 8261 (pt 6) | 14, 28 | 10.7, 5.2 | 19 | 1–1 or 1–5 | CASSIDQGGNQPQHF | ADQ19349.1 | 80 | No |
| 12872 (pt 6) | 28, 84 | 6.6, 7.1 | 5–6 | 1–3 | CASSLSAGDQPQHF | ADQ19293.1 | 80 | No |
| 10041 (pt 6) | 28 | 6.2 | 19 | 1–5 | CASSIRQARTQPQHF | ADQ19349.1 | 80 | Yes |
| 11938 (pt 6) | 84 | 5.7 | 19 | 1–5 | CASSIDQGGNQPQHF | ADQ19349.1 | 80 | Yes |