Table 2. MYC and ITGA1 protein expression correlates in colorectal cancers.
MYC score | Total | |||
---|---|---|---|---|
0 | 1 | 2 | ||
ITGA1 score | ||||
0 | 21 | 2 | 0 | 23 |
1 | 8 | 15 | 1 | 24 |
2 | 2 | 5 | 11 | 18 |
Total | 31 | 22 | 12 | 65 |
Immunohistochemical expression of MYC and ITGA1 were compared with their respective expression in the normal colonic epithelium as shown in Figure 5 where scores of 0, 1 or 2 were attributed in the tumor relative to the staining intensity observed in the corresponding resection margin for the upper gland/surface epithelium (=0), the lower half of the gland (=1) or stronger than the lower half of the gland (=2). MYC and ITGA1 expressions are significantly correlated in 72.3% of the studied tumors (47 cases, weighted κ=0.70, P<0.0001, bold values).