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. 2016 Mar 18;7(5):576–586. doi: 10.7150/jca.13117

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The inhibitory effects on breast cancer cell proliferation and tumorigenesis after reducing Z38 expression in MCF-7 and MDA-MB-231 cells. (A) Z38 expression level in cells after stable transfection with the following gene silencing plasmids of Z38: shZ38-146, shZ38-227, and the negative control shCtrl. (B) Results of MTT assays. (C) Results of colony formation in agarose. (D and E) Histograms showing the tumor volume and tumor weight of in vivo xenograft experiments, respectively. (F) Histogram showing the tumor growth rate. ^* (p < 0.05) when compared with shZ38-146; ^# (P < 0.05) when compared with shZ38-227.