Figure 3.

Insulin signaling and high-fat diet feeding influence skeletal accumulation of [¹⁸F]-FDG. (a) [¹⁸F]-FDG levels in tibia, femur, L4–L5 vertebrae, and calvaria in control, ΔIR, and control mice treated with insulin (0.5 units per kg body weight). n=5–11 mice per group. (b) Body weights of mice fed a high-fat diet (60% fat) or an isocaloric low-fat diet (10% fat). (c) Blood glucose levels after a 6 h fast in mice fed a high or low fat diet for 12 weeks. (d) [¹⁸F]-FDG levels in tibia, femur, L4–L5 vertebrae, and calvaria. n=8 mice per diet. *P<0.05.