Table 1.

Syntheses of the dethylphosphoryl Oxyma derivatives, 3 and 4, and their half-lives in common organic solvents.

entry	Molecule	Solvent	Half-life (t1/2)a
1	3	DMF	>5 days
2	4	DMF	>5 days
3	3	CH3CN	> 5 days
4	4	CH3CN	> 5 days
5	3	DMSO	12 h
6	4	DMSO	12 h
7	3	H2O	< 3h
8	4	H2O	< 3h
9	3	-b	>30 days
10	4	-b	>30 days

^at_1/2 at room temperatures, t_1/2 was determined via ¹H-NMR (CDCl₃);

^bneat conditions;