Table 3. Plasma pharmacokinetics of paeoniflorin (5) in rats receiving a 30-min intravenous infusion of XueBiJing injection.
| PK parameter | 5 mL/kg (Paeoniflorin, 5.7 mg/kg) | 10 mL/kg (Paeoniflorin, 11.4 mg/kg) | 20 mL/kg (Paeoniflorin, 22.8 mg/kg) |
|---|---|---|---|
| C30 min (μmol/L) | 24.6±5.0 | 48.6±3.6 | 95.3±16.8 |
| AUC0-∞ (μmol/L·h) | 13.8±3.2 | 28.4±3.7 | 56.0±9.8 |
| t1/2 (h) | 0.37±0.15 | 0.43±0.09 | 0.47±0.21 |
| MRT (h) | 0.55±0.05 | 0.56±0.03 | 0.58±0.04 |
| CLtot, p (L·h−1·kg−1) | 0.90±0.22 | 0.85±0.11 | 0.87±0.16 |
| VSS (L/kg) | 0.26±0.02 | 0.26±0.02 | 0.31±0.06 |
C30 min, concentration at 30 min after dosing; AUC0-∞, area under the plasma concentration-time curve from zero to infinity; t1/2, elimination half-life; MRT, mean residence time; CLtot,p, total plasma clearance; VSS, apparent volume of distribution at steady state.