Table 4. Renal and hepatic excretion of paeoniflorin (5) in rats receiving a 30-min intravenous infusion of XueBiJing injection at 10 mL/kg.

PK parameter	10 mL/kg (Paeoniflorin, 11.4 mg/kg)
Urine data
Cum.Ae-U (μmol)	3.07±0.51
CLR (L·h−1·kg−1)	0.42±0.07
fe-U (%)	50.2±8.9
CLR/(GFR×fu)	1.43±0.25
Bile data
Cum.Ae-B (μmol)	0.18±0.05
CLB (L·h−1·kg−1)	0.03±0.01
fe-B (%)	3.34±0.94

Cum.A_e-U, cumulative amount excreted into urine; CL_R, renal clearance; f_e-U, fraction of dose excreted into urine; GFR, glomerular filtration rate; Cum.A_e-B, cumulative amount excreted into bile; CL_B, biliary clearance; f_e-B, fraction of dose excreted into bile.