Table 5. Results from dose proportionality assessment for plasma paeoniflorin (5) in rats receiving a 30-min intravenous infusion of XueBiJing injection at 5, 10, and 20 mL/kg.

PK parameter	r	P	Slope (90% CI)	Conclusion
Plasma Cmax	0.96	0.000000000002	0.98 (0.87–1.09)	Linear
Plasma AUC0-∞	0.96	0.00000000001	1.02 (0.90–1.14)	Linear

Critical intervals were 0.84–1.16 for the plasma data with XueBiJing injection. The term r denotes the correlation coefficient. Correlations were statistically significant with a P<0.05. The term “linear” was concluded statistically if the 90% confidence interval (90% CI) for slope was contained completely within the critical interval; “inconclusive” was concluded statistically if the 90% CI lay partly within the critical interval; “nonlinear” was concluded statistically if the 90% CI was entirely outside the critical interval.