Table 6. Comparative plasma pharmacokinetics of paeoniflorin (5) in rats receiving an intravenous bolus dose of XueBiJing injection at 10 mL/kg (each milliliter of injection containing 1.14 mg of (5) or purified paeoniflorin at 11.4 mg/kg (paeoniflorin being dissolved in vehicle of XueBiJing injection).
| PK parameter | XueBiJing injection | Purified paeoniflorin |
|---|---|---|
| C5 min (μmol/L) | 72.8±2.6 | 68.5±9.0 |
| AUC0-∞ (μmol/L·h) | 26.3±4.2 | 26.3±4.1 |
| t1/2 (h) | 0.26±0.03 | 0.26±0.01 |
| MRT (h) | 0.36±0.05 | 0.37±0.04 |
| CLtot, p (L·h−1·kg−1) | 0.92±0.16 | 0.80±0.11 |
| VSS (L/kg) | 0.24±0.02 | 0.21±0.03 |
C5 min, concentration at 5 min after dosing; AUC0-∞, area under the plasma concentration-time curve from zero to infinity; t1/2, elimination half-life; MRT, mean residence time; CLtot,p, total plasma clearance; VSS, apparent volume of distribution at steady state. Paeoniflorin was dissolved in the vehicle that was used to prepare XueBiJing injection.