Table 7. Tissue penetration of paeoniflorin (5) after an intravenous bolus dose of XueBiJing injection at 10 mL/kg in rats.
| PK parameter | Lung | Heart | Brain | Kidney | Liver | Plasma |
|---|---|---|---|---|---|---|
| Cmax (μmol/L) | 28.1±2.5 | 16.4±1.3 | 0.89±0.05 | 378±114 | 25.4±7.4 | 80.3±3.6 |
| AUC0-∞ (μmol/L·h) | 12.0±1.5 | 6.55±0.85 | 0.43±0.08 | 121±24 | 12.4±3.2 | 28.2±2.9 |
| t1/2 (h) | 0.30±0.02 | 0.27±0.01 | 0.33±0.02 | 0.20±0.00 | 0.26±0.04 | 0.21±0.02 |
Cmax, concentration at 5 min after dosing for heart, lung, brain, kidney, and plasma and concentration at 15 min after dosing for liver; AUC0-∞, area under the tissue or plasma concentration-time curve from zero to infinity; t1/2, half-life.