Table 1. Studies of endoplasmic reticulum stress in cardiovascular physiology function.

Reference	Protein level	Experiment cell	Effect	Mild ERS	Severe ERS	ERS inducer
Riek et al 62	β1, β2 integrin	Monocyte	Enhance adhesion; enhance proliferation	Yes	No	Thapsigargin
Nakamura et al 63	Bip/T-cadherin	Human retinal microvascular endothelial cells (HRMEC)	Enhance proliferation; enhance migration	Yes	No	Tunicamycin Thapsigargin
	Bip/T-cadherin	Human retinal microvascular endothelial cells (HRMEC)	Suppress proliferation; suppress migration	No	Yes	Tunicamycin Thapsigargin
	Bip/T-cadherin	OIR model mice	Enhance neovascularization	Yes	No	Tunicamycin Thapsigargin
Yang et al 67	GRP78, CHOP, caspase 12	Human umbilical vein endothelial cells (HUVECs)	Induce cells apoptosis	No	Yes	Intermittent/persistent hypoxia
Yi et al 70	XBP1, GRP94, ATF6	Vascular smooth muscle cells (VSMC); SD rats aortic endothelialcell cells	Suppress abnormal proliferation and migration	No	Yes	Tunicamycin