Figure 2.

The mean plasma concentration-time curves of (A) midazolam (2 mg/kg), (B) dextromethorphan (5 mg/kg), (C) omeprazole (2 mg/kg), (D) theophylline (1 mg/kg), (E) chlorzoxazone (1 mg/kg) and (F) diclofenac (0.5 mg/kg) after the intravenous administration of the cocktail solutions to rats in the absence (open triangle) or presence (solid square) of caderofloxacin. Caderofloxacin (9 mg/kg) was given via an intragastrical administration twice daily for 14 d. The data are expressed as the mean±SD (n=6). ^bP<0.05, ^cP<0.01 vs in the absence of caderofloxacin.