Figure 4.

(A) The formation of 6-hydroxychlorzoxazone in the hepatic microsomes of control (open triangle) and caderofloxacin-treated (solid square) rats. Insets represent the corresponding Eadie–Hofstee plots. (B) The effects of diethyldithiocarbamate (DDC, a CYP2E1 inhibitor) on the formation of 6-hydroxychlorzoxazone in the hepatic microsomes of control (white bar) and caderofloxacin-treated (shaded bar) rats. Caderofloxacin (9 mg/kg) was given via an intragastrical administration twice daily for 14 d. The data are expressed as the mean±SD (n=4). ^bP<0.05, ^cP<0.01 vs control rats. ^eP<0.05, ^fP<0.01 vs without inhibitor.