Table 1. Main pharmacokinetic parameters of probes after intravenous administration of the cocktail solutions to rats in absence or presence of caderofloxacin. Caderofloxacin (9 mg/kg) was given once via intragastrical administration 15 min ahead of the cocktail solutions. Data are expressed as mean±SD (n=6).
| Probes | PK parameters | In absence | In presence |
|---|---|---|---|
| Midazolam | t1/2 (min) | 25.3±5.1 | 30.7±3.3 |
| AUC0-∞ (ng·min/mL) | 34750.3±3311.6 | 33759.6±9465.4 | |
| Cl (mL/kg·min−1) | 58.0±5.6 | 65.7±29.1 | |
| Dextromethorphan | t1/2 (min) | 99.1±6.4 | 110.7±14.5 |
| AUC0-∞ (ng·min/mL) | 38299.0±2839.5 | 35369.4±7947.1 | |
| Cl (mL/kg·min−1) | 131.1±10.0 | 148.3±38.9 | |
| Omeprazole | t1/2 (min) | 19.2±0.6 | 29.6±14.0 |
| AUC0-∞ (ng·min/mL) | 46715.8±2816.7 | 49691.6±3009.5 | |
| Cl (mL/kg·min−1) | 42.9±2.6 | 40.4±2.4 | |
| Theophylline | t1/2 (min) | 100.6±2.0 | 123.2±25.8 |
| AUC0-∞ (ng·min/mL) | 285172.9±40807.1 | 279491.3±19773.6 | |
| Cl (mL/kg·min−1) | 3.6±0.5 | 3.6±0.3 | |
| Chlorzoxazone | t1/2 (min) | 30.2±8.6 | 31.0±2.8 |
| AUC0-∞ (ng·min/mL) | 137878.2±20450.7 | 144480.9±12261.9 | |
| Cl (mL/kg·min−1) | 7.4±1.0 | 7.0±0.7 | |
| Diclofenac | t1/2 (min) | 97.0±14.7 | 107.1±22.9 |
| AUC0-∞ (ng·min/mL) | 47554.8±7358.5 | 46399.8±7831.5 | |
| Cl (mL/kg·min−1) | 10.7±1.7 | 11.0±1.6 |