Table 3. Kinetic parameters for formation of 6-hydroxychlorzoxazone in hepatic microsomes of control and caderofloxacin-treated rats. Caderofloxacin (9 mg/kg) was given via intragastrical administration twice daily for 14 d. Data are expressed as mean±SD (n=4). ^bP<0.05, ^cP<0.01 vs control rats.

Parameters	Control	Caderofloxacin treatment
Km,1 (μmol/L)	45.61±13.64	53.68±5.56
Vmax,1 (μmol·min−1·g−1)	0.29±0.04	0.35±0.04
Vmax,1/Km1 (mL·min−1·g−1)	6.63±1.06	6.47±0.81
Km,2 (μmol/L)	838.18±48.76	934.23±10.58b
Vmax,2 (μmol·min−1·g−1)	2.02±0.10	2.64±0.09c
Vmax,2/Km2 (mL/·min−1·g−1)	2.42±0.03	2.83±0.07c