Table 1. Pharmacokinetic parameters of (+)-C in plasma.

Parameters	(+)-C-only (po)	(+)-C+Pue (po)	(+)-C-only (iv)	(+)-C+Pue (iv)
AUC0–12 h (mg/L·h)	3.02±0.70	1.74±0.72b	35.30±5.44	43.87±4.99
MRT0–12 h (h)	4.78±0.67	4.25±0.39	1.78±0.31	1.80±0.19
Tmax (h)	0.25±0.068	0.33±0.19	0.05	0.05
Cmax (mg/L)	0.98±0.33	0.76±0.32	88.24±19.65	80.85±10.35
Fab (%)	4.24±0.35	2.23±0.55c	NA	NA

Note: Data represent mean±SD (n=5). NA, not applicable.

Compared to (+)-C (po)-only, ^bP\<0.05; ^cP\<0.01.