Table 4. The effect of P-gp/MRP-2 inhibitors on the transport of Pue across Caco-2 cell monolayers at 60 min.

Group	Papp (10−6cm/s)
	AP→BL	BL→AP	PDR
Pue 300 μmol/L	1.86±0.50	5.22±0.55	2.80
Pue 300 μmol/L+10 μmol/L Cyclosporin A	6.50±0.49c	12.11±3.19	1.86
Pue 300 μmol/L+50 μmol/L MK-571	6.59±0.62b	3.81±0.79b	0.58

Note: Data represent mean±SD (n=3).

Compared with Pue-only group, ^bP\<0.05; ^cP\<0.01.