Figure 2.

Model for Membrane recruitment of AP-1B. This figure represents a schematic drawing of the putative membrane recruitment of AP-1B indicating the rotation of the µ1B subunit upon membrane recruitment. Note that the C-terminus of µ subunits is organized in subdomains A and B as illustrated in the membrane-bound form. Whereas subdomain A binds to YxxØ sorting signals and thus cargo proteins, subdomain B probably binds to PtdIns(3,4,5)P₃. Finally, Arf6 most likely binds to both γ and β1 adaptin. Abbreviations PI(3,4,5)P₃, PtdIns(3,4,5)P₃