Table 2.
Alignment of “loca” region in µ1 genes from various species (corresponding to residues 333 – 346 in µ1B)
| µ1 homolog | “loca” sequence | Net charge |
|---|---|---|
| µ1A H. sapiens | KWVPENSEIVWSIK | 0 |
| µ1B H. sapiens | KYVPERNVVIWSIK | +2 |
| µ1A D. rerio | KWVPENSEIVWSIK | 0 |
| µ1B D. rerio | KYVPEKNLVVWSIK | +2 |
| µ1C D. rerio | KWVPEKSAVEWNIK | +1 |
| Unc-101 C. elegans | KYTPEQSAFVWTIK | +1 |
| Apm-1 C. elegans | KYVPELNAIVWSIR | +1 |
| µ1 D. melanogaster | KYAPEQNAIIWTIK | +1 |
| APM1 S. cerevisiae | KYVPEKSAILWKIR | +3 |
Basic residues are shown in blue, acidic residues are shown in red, and underlined residues correspond to those that were mutated in µ1Bloca.