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. Author manuscript; available in PMC: 2016 Apr 5.
Published in final edited form as: Annu Rev Physiol. 2015;77:105–129. doi: 10.1146/annurev-physiol-061214-111754

Table 1.

Sites of expression of Hedgehog pathway genes in steroidogenic tissues

Tissue Gene Localization
Adrenal gland Shh Subcapsule
Ptch, Gli Capsule
Testis Dhh Sertoli precursor cells
Ptch, Gli Interstitial cells, Leydig cells, and endothelial cells
Ovary Dhh, Ihh Granulosa cells of antral follicles
Ptch, Gli Theca cells surrounding follicles; expression lost during ovulation; low expression levels in ovarian stroma

Abbreviations: Dhh, Desert hedgehog; Gli, Glioma-associated oncogene; Ihh, Indian hedgehog; Ptch, Patched; Shh, Sonic hedgehog.