Figure 3. MeCP2 enrichment depends weakly on mCpG%.

(a) GC% (green), mean MeCP2 enrichment (purple) and mCpG% (red) around proximal (that is, located within 500 bp of a TSS, solid) and distal (dashed) CGIs. (b) Gaussian graphical model (Methods) describing the full partial correlations between the MeCP2 ChIP, Input, GC%, CpG%, mCpG% and mCpH%, all evaluated using 150 bp binning. (c) Same as b but using MeCP2 ChIP-seq data from Skene et al.⁴ (no Input was available) and methylation data from Lister et al.²⁴ (d) Same as b but using ES cell MeCP2 ChIP and Input from Baubec et al.¹⁷ and methylation data from Stadler et al.²⁵ (no mCpH% was available). (e) Same as b but using MeCP2 ChIP and Input from Chen et al.²⁷ and methylation data from Lister et al. (f) Same as b but using MeCP2 ChIP and Input from Gabel et al.⁹ and methylation data from Lister et al.²⁴