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. 2016 Mar 24;7:11075. doi: 10.1038/ncomms11075

Figure 5. Alterations to phenotypic and functional progenitor levels in old mice.

Figure 5

(a) Lymphoid-primed multi-potent progenitors (LMPPs) as percentage of LSK cells in young (N=15) and old (N=7) mice. Data are from five independent experiments. (b) Frequencies of CLPs in total BM in young (N=9) and old (N=6) mice. Data are from five independent experiments. (c) Gating strategy for identification of myelo-erythroid progenitor populations. (d) Representative FACS plots of myelo-erythroid progenitors in BM from young (top) and old (bottom) Vwf-EGFP mice. Numbers indicate percentage of Lin−Sca-1−c-Kit+ cells. (e) Frequencies of myelo-erythroid progenitor cells as percentage of Lin−Sca-1−c-Kit+ cells in young (Y: N=6) and old (O: N=6) mice. Data are from six independent experiments. (f) Frequencies of CFU-Mk in unfractionated BM from young (N=3) and old (N=2) mice. Data are from a single experiment. (g) Frequencies of CFU-GM in unfractionated BM from young (N=3) and old (N=2) mice. Data are from a single experiment. (h) Frequencies of CFU-B in unfractionated BM from young (N=3) and old (N=2) mice. Data are from a single experiment. (i) Platelet counts in peripheral blood from young (N=22) and old (N=11) mice. Data are from three independent experiments. (j) Plasma levels of thrombopoietin in young (N=5) and old mice (N=5) each measured in triplicate by ELISA. Data are from a single experiment. All data are mean values±s.e.m. *P<0.05; **P<0.01; ***P<0.001 (Student's t-test).

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