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. 2016 Mar 24;7:11080. doi: 10.1038/ncomms11080

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LTD was induced by pairing a low-frequency stimulation (500 pulses at 1 Hz) with −40 mV postsynaptic depolarization (indicated by a dark line) in untransfected CA1 neurons or neurons transfected with BRAG1-E849K (a; n=9), BRAG1-Q801P (a; n=8), wild-type BRAG1 (c; n=7), BRAG1 RNAi (e; n=7), BRAG1 RNAi+wild-type BRAG1 (e; n=9) or BRAG1 RNAi+BRAG1-ΔCt (g; n=6). Insets: sample traces of evoked AMPAR-mediated synaptic responses recorded at −60 mV before pairing (thin line) and 20 min after pairing (thick line) from control or transfected cells as indicated. Scale bars, 20 pA, 20 ms. (b,d,f,h) Normalized average steady-state AMPAR-mediated responses in paired (LTD induction) and control (unpaired pathway). * Indicates significance (P≤0.05).