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. 2016 Mar 24;7:11057. doi: 10.1038/ncomms11057

Figure 1. ELL induces c-Myc degradation.

Figure 1

(a) Co-transfection of ELL induces the protein degradation of wild-type c-Myc as well as the T58A and P57S mutants in HEK293 cells. (b) Co-transfection of ELL induces the protein degradation of the c-Myc S62E mutant. (c) Overexpression of ELL in HCT116 cells reduces endogenous c-Myc protein degradation in a dose-dependent manner. (d) shRNA-mediated ELL knockdown in HCT116 cells by ELL-shRNAs (ELL-shRNA-1 and ELL-shRNA-2) enhances endogenous c-Myc protein level.