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. 2016 Mar 24;7:11057. doi: 10.1038/ncomms11057

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(a–c) The HA-tagged wild-type c-Myc and 23 HA-tagged c-Myc mutants were co-transfected with Flag-ELL into HEK293T cells, the expressions of wild-type c-Myc and c-Myc mutants were detected by anti-HA antibody. ELL does not induce degradation of the K51/52R, K397R and K430R c-Myc mutants. (d) Compared with that of the wild-type c-Myc, the poly-ubiquitination of the K51/52R, K397R and K430R mutants by ELL was diminished. (e) ELL does not promote poly-ubiquitination of the c-Myc(4K/R) mutant.