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. 2016 Mar 24;7:11057. doi: 10.1038/ncomms11057

Figure 8. ELL suppresses colon tumour xenograft growth.

Figure 8

(a) Overexpression of ELL inhibits HCT116 tumour xenograft growth in nude mice (n=5), but overexpression of the ELL(C595A) mutant has no obvious effect (n=5 or n=4, after week 4). Data are presented as mean ±s.e.m. (b) Tumours harvested from the nude mice after 6 weeks. (c) The weight of the tumours after 6 weeks. control, n=5; ELL(C595A), n=4 (one mouse died at week 4); ELL, n=1 (no tumour grew in other four mice). Data are presented as mean ±s.e.m. (d) Expression of ELL, ELL(C595A) and c-Myc in the tumours is confirmed by western blot analysis. (e) Representative pictures of normal colon tissues and colon cancer specimens stained with an anti-ELL antibody (upper panel) or anti-c-Myc antibody (lower panel). (f,g) Expression of c-Myc (f) and ELL (g) in human colon cancer specimens (n=90) and normal colon tissues (n=86) as revealed by immunohistochemistry using an anti-c-Myc and anti-ELL antibodies, respectively.