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. 2016 Apr 4;16:263. doi: 10.1186/s12885-016-2299-9

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© Delforoush et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of melflufen in subcutaneous DOHH-2 xenografted mice. Presented as tumor volume (a), survival (b) and body weight change (c). Mice in control group (n = 5) gained weight and showed no signs of toxicity, but individuals were prematurely sacrificed due to tumor size on day 33 (n = 2) and 35 (n = 2). Animals in vincristine control group had excellent tumor control but lost weight and one animal was sacrificed on day 25, one on day 33 due to >20 % weight reduction. Animals treated with melflufen had no weight loss but significant tumor growth reduction on day 33 (p < 0.05). Log-rank test showed a significant difference in survival between the control group and the melflufen treated group (p = 0.0144). In A and C mean values with SEM are displayed