Table 3.

Cytotoxic activity (as IC₅₀ μM) of standard drugs and melflufen in the panel of cell lines

Drugs/Cell lines	Vincristine	Doxorubicin	4-HC	Etoposide	Cytarabine	Bortezomib	Melphalan	Melflufen
DB	0.013	0.052	25	2.4	30	0.0020	44	0.92
DOHH-2	0.030	0.050	22	2.3	9.6	0.0063	17	0.39
HDLM-2	0.0023	0.15	16	3.9	0.83	0.0031	9.3	0.088
KM-H2	0.0025	0.034	5.7	0.65	>100	0.0024	8.6	0.22
L-428	0.14	0.089	24	2.0	31	0.0044	9.4	0.73
Ly-3	0.0026	0.044	0.77	0.24	1.4	0.0028	0.52	0.011
RC-K8	0.14	0.059	21	2.7	8.7	0.0071	12	0.45
SU-DHL-6	0.0014	0.053	6.7	2.7	7.0	0.0023	38	0.42
SU-DHL-10	0.00026	0.19	17	49	0.080	0.0047	29	0.71
U-2932	0.0037	0.18	17	3.5	0.84	0.0038	19	0.52
U-2940	0.020	0.026	1.6	0.34	0.91	0.0052	9.8	0.12
WSU-NHL	0.0015	0.032	3.8	1.5	0.17	0.0028	6.9	0.077