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. 2015 Nov 20;30(2):120–133. doi: 10.7555/JBR.30.20150108

Fig. 2. Potency determination of NSAIDs.

Fig. 2

A: Growth inhibition of H69AR and parental H69 cells by sulindac sulfide or indomethacin was measured after 3 days of treatment. H69AR (B) and H69 (C) cells were treated with increasing concentrations of sulindac sulfide or indomethacin before addition of subtoxic concentrations of Dox (500 nmol/L and 25 nmol/L, respectively) to determine the concentration range over which the NSAIDs enhance sensitivity to Dox. Data is expressed as the difference between cytotoxicity of NSAID alone versus NSAID+Dox (Single factor ANOVA, P≤0.05).