Table 2.

Lung function measures at screening and baseline (ITT population)

Lung function measures	Placebo	VI 6.25 μg	VI 12.5 μg	VI 25 μg	Total
	N = 115	N = 114	N = 113	N = 114	N = 456
Screening
Pre-bronchodilator PEF (L/min)
n	115	114	113	114	456
Mean	185.05	178.35	179.22	177.09	179.94
SD	59.30	55.67	60.57	55.68	57.74
Post-bronchodilator PEF (L/min)
n	115	114	113	114	456
Mean	238.79	232.29	234.54	228.37	233.51
SD	67.41	69.80	69.79	72.29	69.71
Percentage of pre- to post-bronchodilator PEF (%)
n	115	114	113	114	456
Mean	76.95	76.86	75.87	78.02	76.93
SD	9.18	9.57	10.90	8.17	9.50
Pre-bronchodilator FEV1 (L)
n	91	91	97	102	381
Mean	1.405	1.370	1.374	1.361	1.377
SD	0.408	0.423	0.445	0.429	0.426
Post-bronchodilator FEV1 (L)
n	99	98	96	103	396
Mean	1.700	1.702	1.699	1.680	1.695
SD	0.457	0.532	0.465	0.496	0.487
Pre-bronchodilator FEV1 (% predicted)a
n	91	91	97	102	381
Mean	86.83	82.92	85.04	84.08	84.70
SD	19.83	17.00	17.34	16.77	17.73
Post-bronchodilator FEV1 (% predicted)a
n	99	98	96	103	396
Mean	106.81	101.10	104.34	104.58	104.22
SD	20.94	18.47	16.68	19.97	19.15
Baseline
Pre-bronchodilator PEF (L/min)
n	115	114	113	114	456
Mean	186.27	185.08	181.24	179.39	183.00
SD	60.64	59.17	55.19	56.82	57.88
Percentage of pre- to post-bronchodilator PEF (%)
n	115	114	113	114	456
Mean	77.77	79.54	77.58	79.13	78.51
SD	10.49	9.09	10.11	9.77	9.88
Pre-bronchodilator FEV1 (L)b
n	96	91	97	103	387
Mean	1.367	1.408	1.361	1.365	1.374
SD	0.421	0.454	0.398	0.398	0.416
Pre-bronchodilator FEV1 (% predicted)a,b
n	96	91	97	103	387
Mean	84.37	83.99	85.43	85.75	84.91
SD	19.35	16.99	17.66	18.38	18.08

FEV ₁ forced expiratory volume in one second, ITT intention-to-treat, PEF peak expiratory flow, SD standard deviation, VI vilanterol

^a% predicted FEV₁ data are posthoc analyses

^bThree children had post-dose FEV₁ at baseline and were not included in any FEV₁ secondary endpoint analyses