Table 3.
Human genes absent from CyCMV Mauritius
| Gene | CyCMV Ottawa/RhCMV 68.1 Homologue | Functiona | Effect of deletion on viral growth kineticsb | Family |
|---|---|---|---|---|
| RL2 | −/− | - | no effect | |
| RL3 | −/− | - | no data | |
| RL4 | −/− | - | no effect | |
| RL5 | −/− | - | no data | RL11 |
| RL6 | −/− | - | no effect | RL11 |
| RL7 | −/− | - | no data | |
| RL8 | −/− | - | no data | |
| RL9 | −/− | - | no effect | |
| RL10 | −/− | - | no effect | RL11 |
| RL11 | cyRL11/rh05 | IgG Fc-binding glycoprotein | no effect | RL11 |
| RL12 | −/− | Putative membrane glycoprotein | no effect | RL11 |
| RL13 | −/− | Putative membrane glycoprotein | no effect | |
| RL14 | −/− | - | no data | |
| UL1 | −/− | - | no data | RL11 |
| UL2 | −/− | - | modest effect | RL11 |
| UL3 | −/− | - | no effect | |
| UL4 | −/− | - | no effect | RL11 |
| UL5 | −/− | - | no effect | RL11 |
| UL8 | −/− | - | no effect | RL11 |
| UL10 | −/− | Temperance factor in retinal tissueb | no effect | RL11 |
| UL12 | −/− | - | modest effect | |
| UL15 | −/− | - | no effect | |
| UL16 | −/− | Membrane glycoportein involved in inhibiting Natural Killer cell cytotoxicity | no effect | |
| UL17 | -/rh35 | 7-transmembrane glycoprotein | no effect | |
| UL18 | −/− | MHCI homologue putative membrane protein | no effect | UL18 |
| UL22 | −/− | - | no data | |
| UL39 | −/− | - | no effect | |
| UL40 | -/rh67 | Membrane glycoptrotein | no data | |
| UL58 | −/− | - | no data | |
| UL59 | −/− | - | no effect | |
| UL60 | −/− | - | required for replication | |
| UL61 | −/− | - | no data | |
| UL62 | −/− | - | no effect | |
| UL63 | −/− | - | no data | |
| UL64 | −/− | - | no effect | |
| UL65 | −/− | - | modest effect | |
| UL66 | −/− | - | no data | |
| UL67 | −/− | - | no effect | |
| UL68 | −/− | - | no data | |
| UL80.5 | -/rh109.1 | Capsid Scaffold Protein | no data | Core |
| UL81 | −/− | - | no data | |
| UL101 | −/− | - | required for replication | |
| UL106 | −/− | - | no data | |
| UL107 | −/− | - | no data | |
| UL108 | −/− | - | no data | |
| UL109 | −/− | - | modest effect | |
| UL110 | −/− | - | no effect | |
| UL118 | -/rh151 | - | no effect | |
| UL124 | -/rh156.2 | Membrane glycoprotein latent protein | no data | |
| UL125 | −/− | - | variable critical effect | |
| UL127 | −/− | - | no data | |
| UL129 | −/− | - | no effect | |
| UL143 | −/− | Inhibits Natural Killer cell cytotoxicity | modest effect | |
| UL142 | −/− | Putative membrane protein | no data | |
| UL139 | −/− | Putative membrane glycoprotein | no data | |
| UL138 | −/− | Putative membrane protein | no data | |
| UL137 | −/− | - | no data | |
| UL136 | −/− | Putative membrane protein | no data | |
| UL135 | −/− | Putative secreted protein | no data | |
| UL134 | −/− | - | no data | |
| UL133 | −/− | Putative membrane protein | no data | |
| UL148A | −/− | Putative membrane protein | no data | |
| UL148B | −/− | Putative membrane protein | no data | |
| UL148C | −/− | Putative membrane protein | no data | |
| UL148D | −/− | Putative membrane protein | no data | |
| UL149 | −/− | no data | ||
| UL150 | −/− | Putative Secreted Protein | no data | |
| IRS1 | −/− | Immediate early membrane protein & transcriptional activator/blocks protein kinase R mediated repression of translation | no data | |
| US4 | −/− | - | no effect | US22 |
| US5 | -/rh183 | - | no data | |
| US6 | -/rh185 | Putative membrane glycoprotein/Inhibits TAP mediated ER peptide transport | no data | |
| US7 | −/− | Membrane glycoprotein | no effect | US6 |
| US8 | /-rh187 | MHCI binding Membrane glycoprotein | no effect | US6 |
| US9 | −/− | Membrane glycoprotein involved in cell to cell spread | no effect | US6 |
| US10 | −/− | membrane glycoprotein/Delays trafficking of MHCI | no effect | US6 |
| US15 | −/− | Putative multiple transmembrane protein | no effect | US6 |
| US16 | −/− | Temperance factor and Putative multiple transmembrane protein | no effect | US12 |
| US25 | −/− | - | no effect | US12 |
| US27 | −/− | Virion Envelope Glycoprotein/Potentiates CXCR4 receptorc | no effect | |
| US33 | −/− | - | no effect | GPCR |
| US34 | −/− | Putative secreted protein | no effect | |
| US34A | −/− | Putative membrane protein | no effect |