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. 2016 Mar 30;7:11056. doi: 10.1038/ncomms11056

Figure 2. Cytological changes reminiscent of cells undergoing meiotic cell division processes.

Figure 2

(a) Meiosis-like SYCP3-staining patterns in Max-null ESCs treated with Dox for 10 days. The meiosis-like SYCP3-staining patterns in Max-null ESCs were classified as preleptotene (PL)-, leptotene (L)- and zygotene (Z)-like patterns according to the criteria shown in Supplementary Fig. 3. (b) Frequency of preleptotene-, leptotene- and zygotene-like SYCP3-staining patterns in Max-null ESCs at the indicated days after Dox administration. (c) Co-immunostaining analyses of Max-null ESCs treated with Dox for 9 days with antibodies against SYCP3 and STRA8. (d) Max-null ESCs treated with Dox for 10 days were co-immunostained for SYCP3 and γH2A.X.