Fig. 2.

Angiogenic genes were upregulated in VCAM-1⁺CV-MSCs. a Gene expression profile of VCAM-1⁺CV-MSCs and VCAM-1⁻CV-MSCs determined using Affymetrix oligoarray, with the angiogenic genes valued and expressed in log₁₀. b Several raised angiogenic genes in VCAM-1⁺CV-MSCs were confirmed by real-time PCR, including IL-6, IL-8 [23], HGF, ANG, MMP2, VEGF-A, TGFβ, and bFGF (n = 3–5). ANG angiogenin, ANGPT2 angiopoietin-2, ANGPTL2 angiopoietin-like protein 2, BFGF basic fibroblast growth factor, CCL Chemokine (C-C motif) ligand, CV chorionic villi, CXCL chemokine (C-X-C motif) ligand, EGF epidermal growth factor, HGF hepatocyte growth factor, HIF hypoxia-induced factor, IL interleukin, MMP matrix metalloproteinase, MSC mesenchymal stem cell, TGF transforming growth factor, VCAM-1 vascular cell adhesion molecule 1, VEGF vascular endothelial cell growth factor