Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Potential mechanisms of drug interactions.
Left: Specific ADME properties (absorption, distribution, metabolism, excretion) of drugs which may cause increases in plasma levels and toxicity.
Right: Changes in receptor affinity or synergistic effects with comedication can increase clinical or even toxic effects even if plasma levels remain unchanged.
