MouseOx plus physiological measurements for combined (black), treated (red) and control (blue) groups. Arrow indicates drug administration after reperfusion/un-occlusion for 5 min. (a) Heart rate in beats per minute (bpm), 0–5 min (baseline measurements), 65 min (reperfusion/un-occlusion and drug administration), 70 and 75 min (reperfusion). (b) Pulse distention measuring vessel diameter (µm), 0–5 min (baseline), 65 min (reperfusion/un-occlusion and drug administration), 70 and 75 min (reperfusion). Combined (N = 30), control (N = 15), treated (N = 15).