Perfusion measurements for combined (black), treated (red), and control (blue) groups. Arrow indicates drug administration after reperfusion/un-occlusion for 5 min. (a) Laser Doppler blood perfusion through middle cerebral artery at time points 0 min (baseline measurements), 5 min (occlusion), 70 min (reperfusion/un-occlusion), and 75 and 80 min (reperfusion). Treated (N = 9), control (N = 9). (b) Laser Speckle whole brain perfusion images through contralateral and ipsilateral cortex at time points 0 min (baseline), 5 min (MCA occlusion) and 80 min (reperfusion) for treated (N of 3) and control (N of 3). Black circles indicate regions of interest, ipsilateral (I) and corresponding contralateral (C) for MCA occlusion at aforementioned time points. (c) Laser Speckle graph for whole brain perfusion through contralateral and ipsilateral cortex at time points 0 minutes (baseline measurements), 5 min (MCA occlusion), and 80 (15 min reperfusion/un-occlusion) treated (N = 3), control (N = 3).