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. 2016 Jan 8;36(4):709–720. doi: 10.1177/0271678X15625077

Figure 5.

Figure 5.

Long-term effects of ADA 3–6 h after washout. (a) ADA was added to 32℃ pre-incubation solution (NMDG solution). (b) ADA pre-incubation increased the eFP detection rate (% of total trials). The eFP counts were measured 3–6 h after the pre-incubation and the washout of NMDG solution. (c) Raw waveform of striatal firing response to a 300-ms photo-stimulation. The spikes were observed mainly late in the photo-stimulation. Top bar indicates the photo-stimulation period. The right inset illustrates an expanded single spike (at the arrow). (d) Averaged peri-stimulus time histogram (PSTH) of isolated spike responses (n = 48). (e) Raw waveform obtained from ADA pre-incubated slice. The onset of spike responses to the photo-stimulation was accelerated. (f) Averaged PSTH from the ADA pre-incubated slice (n = 28). (g) ADA pre-incubation significantly increased the mean rate of optogenetically evoked firings during the 150 ms after the onset of the photo-stimulation (p < 0.05).