Table 1.
Summary statistics for ADNI samples by diagnosis.
| ADNI 1 (n = 699) | CN (n = 195) | SMC | EMCI | LMCI (n = 338) | AD (n = 166) | Diff P |
|---|---|---|---|---|---|---|
| WMHva (SD) | 0.8 (2) | – | – | 0.9 (3) | 1.3 (3) | 0.07 |
| CI (+/−)b | 18+,177− | – | – | 30+,308− | 13+,153− | 0.90 |
| Age, Y (SD) | 75 (7) | – | – | 75 (7) | 76 (7) | 0.22 |
| Sex (F/M) | 88 F, 107 M | – | – | 117 F, 221 M | 75 F, 91 M | 0.018 |
| BP (systolic) | 133 (15) | – | – | 133 (17) | 135 (18) | 0.35 |
| BP (diastolic) | 73 (10) | – | – | 74 (10) | 73 (9) | 0.61 |
| MMSE (SD) | 29 (1) | – | – | 27 (2) | 23 (2) | <0.001 |
| Education, Y (SD) | 16 (3) | – | – | 16 (3) | 15 (3) | <0.001 |
| APOE ɛ4 status (+/−) | 53+,142− | – | – | 185+,153− | 112+,54− | <0.001 |
| rs6971 genotype (LAB/MAB/HAB) | 20/88/87 | – | – | 25/135/178 | 18/66/82 | 0.33 |
| ADNI GO and 2 (n = 631) | (n = 129) | (n = 40) | (n = 242) | (n = 122) | (n = 98) | Diff P |
| WMHvc (SD) | 6.8 (13) | 8.5 (11) | 7.3 (9) | 7.7 (10) | 8.7 (10) | 0.70 |
| CI (+/−)b | 6+,113−,10 NA | 40 NA | 20+, 184−, 38 NA | 6+, 75−, 41 NA | 1+, 35−, 62 NA | 0.35 |
| Age, Y (SD) | 74 (6) | 72 (5) | 71 (7) | 72 (8) | 75 (8) | <0.001 |
| Sex (F/M) | 62 F, 67 M | 27 F, 13 M | 102 F, 140 M | 52 F, 70 M | 38 F, 60 M | 0.025 |
| BP (systolic) | 134 (16) | 131 (17) | 132 (17) | 132 (18) | 131 (17) | 0.76 |
| BP (diastolic) | 74 (10) | 72 (9) | 73 (9) | 73 (10) | 74 (10) | 0.87 |
| MMSE (SD) | 29 (1) | 29 (1) | 28 (2) | 28 (2) | 23 (2) | <0.001 |
| Education, Y (SD) | 16 (3) | 17 (3) | 16 (3) | 16 (3) | 16 (3) | 0.16 |
| APOE ɛ4 status (+/−) | 34+,95− | 12+,28− | 105+,137− | 69+,53− | 66+,32− | <0.001 |
| rs6971 genotype (LAB/MAB/HAB) | 19/51/59 | 5/20/15 | 26/108/108 | 9/56/57 | 10/42/46 | 0.75 |
Volumes are in mm3, normalized to a standard space.
Sample sizes for MRI cerebral infarcts (CI) are different than those indicated in column headers, some non-overlapping subjects were evaluated for CI: ADNI1 (nCN = 196, nLMCI = 339, nAD = 167), ADNI GO and 2 (nCN = 123, nEMCI = 207, nLMCI = 83, nAD = 36). cVolumes are in mm3. Continuous variables (age, education, MMSE, and BP) were analyzed for diagnosis group differences using ANOVA (two-tailed). Factor variables (sex, CI, APOE ɛ4 status, and rs6971 genotype) were analyzed using Fisher’s exact test (two-tailed).
LAB: low affinity binders (rs6971 A/A); MAB: medium affinity binders (rs6971 A/G); HAB: high affinity binders (rs6971 G/G); MAF: minor allele frequency; WMHv: white matter hyperintensity volume; CI: cerebral infarcts detected by MRI; MMSE: mini mental status examination; APOE: Apolipoprotein E; BP: blood pressure (mmHg); SD: standard deviation; M: male; F: female; Y: years; CN: cognitively normal; SMC: some memory concern; EMCI: early mild cognitive impairment; LMCI: late mild cognitive impairment; AD: Alzheimer’s disease.