Skip to main content
. 2016 Apr;54(4):584–593. doi: 10.1165/rcmb.2014-0425OC

Figure 3.

Figure 3.

Ablation of Wnt10b leads to an augmented T helper (Th) 2 response after HDM challenge. (A) ELISA for IL-4 and IL-13 show significant increase in Wnt10b−/− mice after HDM challenge compared with littermate controls (n = 3–6/group, **P < 0.01 and *P < 0.05 respectively, Mann-Whitney U test, data are presented as mean ± SD). (B) mRNA expression increase of the Th2-inducing chemokine, chemokine (C-C motif) ligand 2 (CCL2), and the Th2/alternatively activated macrophage marker, arginase 1 (Arg1), in BAL cells of Wnt10b−/− mice after HDM challenge (n = 3–6/group; P = 0.057 and *P < 0.05 respectively, Mann-Whitney U test, data are presented as mean ± SD). GAPDH, gyceraldehyde-3-phosphate dehydrogenase.