Figure 4.

CD90.2-enriched splenic T cells of Wnt10b^−/− mice exhibit increased GATA3 and IL-4 expression after Th2 polarization. (A) Primary T cells from Wnt10b^−/− mice display elevated expression of GATA3 and IL-4 compared with WT cells cultured for 5 days under Th2-promoting conditions. (B) There was no significant difference for T-box expressed in T cells (T-bet) expression and Th1-promoting conditions (n = 3–5/group; *P < 0.05, t test, compiled data from two to three independent experiments, data are presented as mean ± SD). RQ, relative quantification.