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. Author manuscript; available in PMC: 2016 Apr 5.
Published in final edited form as: Gene Ther. 2008 Apr 10;15(18):1257–1270. doi: 10.1038/gt.2008.58

Figure 5.

Figure 5

Mechanism of reovirus-induced cytotoxicity. Mel-888, Mel-624, Mewo and Skmel-28 cells were either left untreated (control), treated with 50 mm ZVAD or 10 PFU/cell reovirus alone or pretreated with 50 µm ZVAD for 1 h before the addition of 10 PFU/cell reovirus. Cells were harvested 48 h after reovirus infection and stained with propidium iodide (PI) before fluorescence-activated cell sorting (FACS) acquisition. Cell death was determined by the proportion of cells staining positive for PI. Data are representative of 2–4 independent experiments.