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. 2015 May 14;1(1):e5. doi: 10.1212/NXG.0000000000000005

Figure 2. The CNTNAP2 locus in disease and localization of its encoded product, CASPR2, at the synapse.

Figure 2

(A) Schematic indicating the functional relationship linking LGI1 and CASPR2 proteins through the voltage-gated potassium channel (VGKC). (B) Schematic indicating the previously reported microdeletions (horizontal bars) of CNTNAP2 in neuropsychiatric conditions (modified from Rodenas-Cuadrado, 2013). The deletion reported in this study, spanning CNTNAP2 exons 2-3, overlaps most of the CNTNAP2 deletions implicated in disorder before. It is represented in red with a halo surrounding it. ADHD = attention-deficit/hyperactivity disorder; ASD = autism spectrum disorder.