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. Author manuscript; available in PMC: 2017 Jan 6.
Published in final edited form as: Prog Biophys Mol Biol. 2016 Jan 6;120(1-3):67–76. doi: 10.1016/j.pbiomolbio.2016.01.002

Figure 7.

Figure 7

1b-R25W is arrhythmogenic in iPSC-CMs. 50 sequential AP traces paced at 1 Hz recorded from iPSC-CMs transfected with either pcDNA3.1 (Vector, A) or 1b-R25W (B) at 36 ± 1°C. (C) Time to 90% repolarization (APD90) recorded from vector-transfected (gray) or R25W-transfected (green) iPSC-CMs (n = 25 & 13, respectively). (D) Ratio of Phase 2 to Phase 3 repolarization times reported as (APD40-APD30)/(APD80-APD70) for either vector-transfected (gray) or 1b-R25W-transfected (green) iPSC-CMs (n = 25 & 13, respectively). (E) Mean coefficient of variation measured from 50 sequential APs paced at 1 Hz from either vector-transfected (gray) or 1b-R25W-transfected (green) iPSC-CMs (n = 22 & 12, respectively). * indicates statistical significance compared to control at p < 0.05. ** indicates statistical significance compared to control at p < 0.01.