Table 2.

Cell Cytotoxicity (IC₅₀ nM) of Ipomoeassin F Analogues 1–4^a,b

	MDA-MB-231	MCF7	HeLa	U937	Jurkat	MCF-10A	NIH/3T3
ipomoeassin F	6.5	43.7	16.4	5.4	6.1	5.4	16.8
1	7129	9090	–c	–	–	–	–
2	131	86.7	133	72.5	139	297	281
3	16.1	33.0	14.9	11.1	9.7	30.7	24.7
4	6848	5929	–	–	–	–	–

^aThe data were obtained from at least two independent experiments, and the standard errors are within 20%.

^bMCF-10A and NIH/3T3 are two nontumor cell lines.

^c–, not tested.